		observed	calculated	calculated	calculated	calculated
J0178	Injection, aflibercept, 1 mg	3,155	$1,756,326,820	11%	2,690,616	559
J2777	Injection, faricimab-svoa, 0.1 mg	2,436	$1,448,279,182	8.7%	53,010,858	13,170
J9271	Injection, pembrolizumab, 1 mg	1,922	$1,242,513,566	7.5%	28,218,856	12,400
J0897	Injection, denosumab, 1 mg	9,797	$978,864,123	5.9%	48,156,716	2,760
Q4205	Membrane graft or membrane wrap, per square centimeter	288	$676,084,642	4.1%	652,199	990
91320	Descriptor not shown (CPT code)	36,800	$663,520,364	4.0%	4,506,697	59
91322	Descriptor not shown (CPT code)	31,346	$564,768,020	3.4%	3,668,923	54
90662	Descriptor not shown (CPT code)	70,747	$524,368,452	3.2%	6,486,542	46
Q4271	Complete ft, per square centimeter	128	$492,819,395	3.0%	373,674	1,758
J0177	Injection, aflibercept hd, 1 mg	1,392	$478,021,052	2.9%	1,820,837	776
J0129	Injection, abatacept, 10 mg (code may be used for medicare when drug administered under the direct supervision of a physician, not for use when drug is self administered)	1,247	$440,285,869	2.6%	13,105,162	8,300
90677	Descriptor not shown (CPT code)	44,623	$374,165,365	2.2%	1,299,916	19
J9144	Injection, daratumumab, 10 mg and hyaluronidase-fihj	765	$323,003,588	1.9%	8,288,764	9,000
Q4191	Restorigin, per square centimeter	135	$309,842,511	1.9%	262,597	1,314
J2781	Injection, pegcetacoplan, intravitreal, 1 mg	857	$286,096,570	1.7%	2,452,956	1,845
90653	Descriptor not shown (CPT code)	43,932	$282,893,756	1.7%	3,476,036	41
Q4164	Helicoll, per square centimeter	60	$253,202,004	1.5%	207,296	945
J3111	Injection, romosozumab-aqqg, 1 mg	1,339	$241,453,680	1.5%	28,416,634	14,490
J0585	Injection, onabotulinumtoxina, 1 unit	3,723	$225,551,859	1.4%	46,383,230	7,660
J0717	Injection, certolizumab pegol, 1 mg (code may be used for medicare when drug administered under the direct supervision of a physician, not for use when drug is self administered)	958	$220,117,291	1.3%	61,165,045	45,600
J9299	Injection, nivolumab, 1 mg	441	$191,282,270	1.1%	7,881,796	14,180
J1602	Injection, golimumab, 1 mg, for intravenous use	1,076	$178,627,979	1.1%	19,861,793	13,650
Q5128	Injection, ranibizumab-eqrn (cimerli), biosimilar, 0.1 mg	470	$169,309,392	1.0%	937,303	1,124
J3262	Injection, tocilizumab, 1 mg	722	$166,745,517	1.0%	35,790,556	39,770
Q4262	Dual layer impax membrane, per square centimeter	38	$144,140,040	0.87%	159,311	821
J3380	Injection, vedolizumab, intravenous, 1 mg	746	$143,429,242	0.86%	8,328,838	8,100
Q4276	Orion, per square centimeter	23	$141,046,740	0.85%	132,581	1,951
J1745	Injection, infliximab, excludes biosimilar, 10 mg	1,377	$137,038,110	0.82%	5,576,857	2,780
J3245	Injection, tildrakizumab, 1 mg	265	$136,974,230	0.82%	1,278,409	4,100
J2782	Injection, avacincaptad pegol, 0.1 mg	568	$123,286,145	0.74%	1,429,067	1,700
J1306	Injection, inclisiran, 1 mg	735	$117,884,330	0.71%	12,438,597	9,372
J2357	Injection, omalizumab, 5 mg	617	$113,422,267	0.68%	3,851,801	4,785
J1569	Injection, immune globulin, (gammagard liquid), non-lyophilized, (e.g., liquid), 500 mg	593	$101,026,285	0.61%	2,848,101	3,245
Q4299	Amnicore pro+, per square centimeter	27	$92,247,911	0.55%	48,872	771
Q4239	Amnio-maxx or amnio-maxx lite, per square centimeter	38	$89,761,821	0.54%	47,039	835
J2778	Injection, ranibizumab, 0.1 mg	753	$86,529,657	0.52%	689,609	450
J9312	Injection, rituximab, 10 mg	336	$76,913,551	0.46%	1,277,588	3,200
J2350	Injection, ocrelizumab, 1 mg	96	$74,686,070	0.45%	1,718,391	13,500
Q4238	Derm-maxx, per square centimeter	34	$72,887,582	0.44%	81,745	1,853
J1568	Injection, immune globulin, (octagam), intravenous, non-lyophilized (e.g., liquid), 500 mg	447	$70,990,965	0.43%	1,950,771	2,940
J1561	Injection, immune globulin, (gamunex-c/gammaked), non-lyophilized (e.g., liquid), 500 mg	206	$69,731,744	0.42%	1,819,367	4,318
J9217	Leuprolide acetate (for depot suspension), 7.5 mg	3,290	$68,531,588	0.41%	495,106	120
Q4295	Amnio tri-core amniotic, per square centimeter	30	$62,702,877	0.38%	39,923	810
J1437	Injection, ferric derisomaltose, 10 mg	969	$59,095,356	0.36%	3,751,157	2,700
Q4221	Amniowrap2, per square centimeter	19	$56,747,569	0.34%	40,666	1,566
Q4290	Membrane wrap-hydro, per square centimeter	27	$51,464,834	0.31%	33,873	456
J2356	Injection, tezepelumab-ekko, 1 mg	206	$49,939,375	0.30%	3,539,998	13,860
Q4282	Cygnus dual, per square centimeter	58	$48,397,896	0.29%	78,519	683
J0881	Injection, darbepoetin alfa, 1 microgram (non-esrd use)	1,179	$46,586,077	0.28%	20,179,038	11,915
Q4294	Amnio quad-core, per square centimeter	21	$42,571,548	0.26%	24,158	900

Source: CMS Medicare Physician & Other Practitioners public use files (Original Medicare Part B fee-for-service). Descriptions of HCPCS Level II codes are the official CMS descriptors, shown verbatim; CPT codes show a ClaimLight category in place of the descriptor. Data year 2024.

Original Medicare Part B fee-for-service only; CMS suppresses provider lines with fewer than 11 beneficiaries. How these figures are computed