		observed	calculated	calculated	calculated	calculated
J0178	Injection, aflibercept, 1 mg	3,143	$2,653,616,697	24%	3,716,326	822
J9271	Injection, pembrolizumab, 1 mg	1,729	$1,047,455,630	9.4%	25,195,372	12,400
J0897	Injection, denosumab, 1 mg	10,191	$804,559,510	7.2%	47,552,605	2,640
J2778	Injection, ranibizumab, 0.1 mg	1,406	$597,487,183	5.3%	2,693,736	945
90662	Descriptor not shown (CPT code)	79,425	$506,624,702	4.5%	7,521,607	51
J0129	Injection, abatacept, 10 mg (code may be used for medicare when drug administered under the direct supervision of a physician, not for use when drug is self administered)	1,193	$432,792,602	3.9%	12,592,718	8,175
90694	Descriptor not shown (CPT code)	47,284	$271,589,451	2.4%	3,966,496	45
90677	Descriptor not shown (CPT code)	32,501	$238,605,877	2.1%	868,792	18
J0717	Injection, certolizumab pegol, 1 mg (code may be used for medicare when drug administered under the direct supervision of a physician, not for use when drug is self administered)	815	$232,670,295	2.1%	51,914,531	48,000
Q4253	Zenith amniotic membrane, per square centimeter	104	$230,450,623	2.1%	319,983	1,352
J9299	Injection, nivolumab, 1 mg	501	$206,567,716	1.8%	9,036,679	14,620
J1602	Injection, golimumab, 1 mg, for intravenous use	974	$198,178,221	1.8%	17,031,178	12,501
J0585	Injection, onabotulinumtoxina, 1 unit	3,544	$194,920,809	1.7%	40,916,298	7,255
J1745	Injection, infliximab, excludes biosimilar, 10 mg	1,367	$160,694,628	1.4%	5,713,703	2,920
J9144	Injection, daratumumab, 10 mg and hyaluronidase-fihj	373	$134,759,091	1.2%	3,744,310	8,100
J2777	Injection, faricimab-svoa, 0.1 mg	931	$116,064,082	1.0%	3,908,584	2,760
J3262	Injection, tocilizumab, 1 mg	519	$108,431,828	0.97%	23,690,002	35,240
J3111	Injection, romosozumab-aqqg, 1 mg	742	$107,565,003	0.96%	14,408,679	13,860
J3380	Injection, vedolizumab, intravenous, 1 mg	544	$104,791,257	0.94%	6,101,149	8,100
J2357	Injection, omalizumab, 5 mg	577	$104,463,833	0.93%	3,547,708	4,395
J2785	Injection, regadenoson, 0.1 mg	6,358	$102,310,070	0.91%	2,139,727	212
J9312	Injection, rituximab, 10 mg	364	$94,170,429	0.84%	1,446,268	3,300
J9217	Leuprolide acetate (for depot suspension), 7.5 mg	4,100	$90,883,949	0.81%	659,032	127
J3245	Injection, tildrakizumab, 1 mg	160	$78,857,640	0.71%	729,716	3,850
J2350	Injection, ocrelizumab, 1 mg	102	$78,177,294	0.70%	1,829,510	13,500
J7326	Hyaluronan or derivative, gel-one, for intra-articular injection, per dose	2,030	$77,731,153	0.70%	105,668	33
Q4197	Puraply xt, per square centimeter	131	$77,359,513	0.69%	369,854	1,775
J1568	Injection, immune globulin, (octagam), intravenous, non-lyophilized (e.g., liquid), 500 mg	465	$74,160,923	0.66%	2,277,598	3,230
J1569	Injection, immune globulin, (gammagard liquid), non-lyophilized, (e.g., liquid), 500 mg	389	$72,656,233	0.65%	2,045,693	3,680
J7320	Hyaluronan or derivitive, genvisc 850, for intra-articular injection, 1 mg	973	$68,893,275	0.62%	5,826,916	3,025
Q4217	Woundfix, biowound, woundfix plus, biowound plus, woundfix xplus or biowound xplus, per square centimeter	58	$60,085,675	0.54%	133,678	1,378
J0881	Injection, darbepoetin alfa, 1 microgram (non-esrd use)	1,122	$54,134,258	0.48%	21,544,190	12,725
J2506	Injection, pegfilgrastim, excludes biosimilar, 0.5 mg	847	$53,858,179	0.48%	430,820	420
J1561	Injection, immune globulin, (gamunex-c/gammaked), non-lyophilized (e.g., liquid), 500 mg	163	$47,930,509	0.43%	1,381,016	4,460
J1439	Injection, ferric carboxymaltose, 1 mg	1,191	$41,554,433	0.37%	47,076,702	28,500
J3304	Injection, triamcinolone acetonide, preservative-free, extended-release, microsphere formulation, 1 mg	1,262	$36,991,496	0.33%	2,755,641	1,312
J0517	Injection, benralizumab, 1 mg	181	$36,957,798	0.33%	282,511	1,321
Q5119	Injection, rituximab-pvvr, biosimilar, (ruxience), 10 mg	415	$36,822,628	0.33%	988,908	2,010
90732	Descriptor not shown (CPT code)	13,931	$36,799,287	0.33%	286,251	15
J7327	Hyaluronan or derivative, monovisc, for intra-articular injection, per dose	1,260	$34,810,341	0.31%	58,394	31
Q4173	Palingen or palingen xplus, per square centimeter	50	$34,571,569	0.31%	96,528	1,392
Q4158	Kerecis omega3, per square centimeter	47	$33,163,723	0.30%	90,113	982
J9035	Injection, bevacizumab, 10 mg	1,925	$32,433,225	0.29%	638,418	150
J2182	Injection, mepolizumab, 1 mg	176	$31,822,981	0.28%	1,408,962	6,455
Q0138	Injection, ferumoxytol, for treatment of iron deficiency anemia, 1 mg (non-esrd use)	1,430	$31,290,843	0.28%	48,530,888	22,950
J7329	Hyaluronan or derivative, trivisc, for intra-articular injection, 1 mg	1,025	$29,131,686	0.26%	2,920,753	1,750
J0885	Injection, epoetin alfa, (for non-esrd use), 1000 units	915	$27,116,792	0.24%	4,253,968	2,920
J7322	Hyaluronan or derivative, hymovis, for intra-articular injection, 1 mg	596	$26,969,057	0.24%	1,297,081	1,537
J1556	Injection, immune globulin (bivigam), 500 mg	49	$26,853,027	0.24%	483,923	4,460
J7318	Hyaluronan or derivative, durolane, for intra-articular injection, 1 mg	1,059	$26,487,637	0.24%	2,479,384	1,680

Source: CMS Medicare Physician & Other Practitioners public use files (Original Medicare Part B fee-for-service). Descriptions of HCPCS Level II codes are the official CMS descriptors, shown verbatim; CPT codes show a ClaimLight category in place of the descriptor. Data year 2022.

Original Medicare Part B fee-for-service only; CMS suppresses provider lines with fewer than 11 beneficiaries. How these figures are computed